I like the idea - I actually had my screen colours inverted completely for some days. However...

Looking at one white on black site for a while and then back at the usual black on white causes some uncomfortable afterimages for me, and while I like spending some time here I usually have Matlab/Mathematica/etc. on my screen and don't like to be distracted by funny colourful spots (that's also why I stopped using inverted colours, it didn't work on remote sessions). Maybe that's just me though...

This could also interfere with accessibility issues, I'm afraid. But actually I like the style if you just invert the colours:  
[![Inverted style][1]][1]
Amplifying the background a bit wouldn't hurt, too IMHO.

I also like the sketchy style and colour choice of e.g. [Crayon Physics  
![Screenshot](http://www.kloonigames.com/crayon/screenshots/crayon_shot_02.jpg)](http://www.crayonphysics.com/)  
but that's probably giving the wrong idea to someone with "advanced" questions...


  [1]: https://i.sstatic.net/rFXZQ.jpg